Top Once Human PvE & PvP Loadouts & Gear

Your combat effectiveness in Once Human hinges on strategic gear and weapon selection. Whether facing corrupted creatures in PvE or assaulting player bases in PvP, a properly optimized build determines victory or defeat.

This guide showcases four top-performing builds in the current meta, complete with recommended weapons, gear modifications, synergy bonuses, and tactical advice. We've tested these configurations—ranging from area-of-effect specialists to critical hit machines—for both solo adventuring and coordinated team play.

New players should consult our Once Human Beginner's Guide for fundamental gameplay knowledge!

Pro Tips for Build Perfection

Maximize synergy: Pair weapon abilities with mods that amplify their specific damage types. Continuous improvement: Higher rarity and upgrade levels significantly boost performance—never settle for obsolete equipment. Prepare alternatives: Maintain secondary loadouts to counter different enemy types or PvP strategies.

Every build shines in specific situations, from boss encounters to large-scale battles or sudden PvP skirmishes. Test different configurations, adjust your modifications, and switch setups based on mission requirements or enemy vulnerabilities.

For peak gaming performance—flawless targeting, efficient resource farming, and seamless inventory control—experience Once Human through BlueStacks. Enjoy superior control schemes and buttery-smooth frame rates for maximum competitive edge.